1241048-04-3Relevant articles and documents
Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists
Bao, Xiaolu,Zhu, Weibo,Yuan, Weidong,Zhu, Xingbo,Yan, Yijia,Tang, Hesheng,Chen, Zhilong
, p. 115 - 127 (2016)
A series of new angiotensin II (Ang II) receptor 1 antagonists were designed, synthesized and evaluated. All compounds showed nanomolar affinities for the angiotensin II type 1 receptor in radioligand binding assays and could reduce blood pressure signifi
Design, synthesis and biological evaluation of new 5-nitro benzimidazole derivatives as AT1 antagonists with anti-hypertension activities
Zhu, Weibo,Da, Yajing,Wu, Dan,Zheng, Huiling,Zhu, Linfeng,Wang, Li,Yan, Yijia,Chen, Zhilong
, p. 2294 - 2302 (2014/04/17)
The design, synthesis, in vitro and in vivo evaluation of 5-nitro benzimidazole with 1,4-disubsituted or 1,5-disubsituted indole derivatives as novel angiotensin II receptor antagonist is outlined. Radioligand binding assays showed that 2-(4-((2-butyl-5-n