1241052-33-4Relevant articles and documents
Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat
Coleman, Paul J.,Schreier, John D.,Roecker, Anthony J.,Mercer, Swati P.,McGaughey, Georgia B.,Cox, Christopher D.,Hartman, George D.,Harrell, C. Meacham,Reiss, Duane R.,Doran, Scott M.,Garson, Susan L.,Anderson, Wayne B.,Tang, Cuyue,Prueksaritanont, Thomayant,Winrow, Christopher J.,Renger, John J.
experimental part, p. 4201 - 4205 (2010/08/22)
Orexins are excitatory neuropeptides that regulate arousal and sleep. Orexin receptor antagonists promote sleep and offer potential as a new therapy for the treatment of insomnia. In this Letter, we describe the synthesis of constrained diazepanes having
