1241680-33-0Relevant articles and documents
Modulating OxyB-Catalyzed Cross-Coupling Reactions in Vancomycin Biosynthesis by Incorporation of Diverse d -Tyr Analogues
Ozturk, Seyma,Forneris, Clarissa C.,Nguy, Andy K.L.,Sorensen, Erik J.,Seyedsayamdost, Mohammad R.
, p. 7309 - 7317 (2018)
We report a general method for synthesizing diverse d-Tyr analogues, one of the constituents of the antibiotic vancomycin, using a Negishi cross-coupling protocol. Several analogues were incorporated into the vancomycin substrate-peptide and reacted with
ApoE secretion modulating bromotyrosine derivative from the Australian marine sponge Callyspongia sp.
Tian, Li-Wen,Feng, Yunjiang,Shimizu, Yoko,Pfeifer, Tom A.,Wellington, Cheryl,Hooper, John N.A.,Quinn, Ronald J.
supporting information, p. 3537 - 3540 (2015/02/19)
High throughput screening of a pre-fractionated natural product library identified 11 active fractions showing ApoE modulation activity. Mass-directed fractionation of one active crude extract from the Australian marine sponge Callyspongia sp. resulted in the isolation of 13 metabolites, including three new bromotyrosine derivatives, callyspongic acid (1), 3,5-dibromo-4-methoxyphenylpyruvic acid (2), N-acetyl-3-bromo-4-hydroxylphenylethamine (3), and ten known compounds (4-13). The structure elucidation of compounds 1-3 was based on their 1D and 2D NMR and MS spectroscopic data. 3,5-Dibromo-4-methoxyphenylpyruvic acid (2) showed weak activity in increasing the apolipoprotein E secretion from human CCF-STTG1 cells at the concentration of 40 μM.
