1241745-70-9

Basic information

• Product Name: 2-fluoro-4-phenylethynyl-phenylamine
• Synonyms: 2-fluoro-4-phenylethynyl-phenylamine
• CAS NO: 1241745-70-9
• Molecular Weight: 211.239
• Mol File: 1241745-70-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-fluoro-4-phenylethynyl-phenylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-4-phenylethynyl-phenylamine(1241745-70-9)
• EPA Substance Registry System: 2-fluoro-4-phenylethynyl-phenylamine(1241745-70-9)

Safety Data

• Hazardous Substances Data: 1241745-70-9(Hazardous Substances Data)

Upstream product

• 29632-74-4 2-fluro-4-iodoaniline 
• 536-74-3 phenylacetylene 

Downstream Products

• 1241745-71-0 2-fluoro-4-(2-phenylethyl)aniline 

Relevant articles and documents

ETHYNYL DERIVATIVES

The present invention relates to compounds of formula (I) wherein R1 is hydrogen, F or CI; L is a bond or lower alkylene; R2 is -(CH2)nO-lower alkyl, lower alkyl substituted by halogen, -(CH2)nC(0)0-lower alkyl, phenyl substituted by lower alkyl or halogen, or is a 5 or 6-membered heteroaryl group, selected from pyridinyl, pyrimidinyl, pyridazinyl, thiazolyl, imidazolyl, pyrazolyl or triazolyl, which are optionally substituted by lower alkyl, halogen, lower alkoxy, =0, benzyloxy, cycloalkyloxy, hydroxy, cyano, lower alkyl substituted by halogen, or by -(CH2)nO-lower alkyl; n is 1, 2 or 3; R3 is hydrogen, lower alkyl or -(CH2)nO-lower alkyl; R4 is phenyl, pyridinyl or pyrimidinyl, optionally substituted by F; Y is CF or CCl; or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomers thereof. The compounds may be used for the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2.