1241920-88-6

Basic information

• Product Name: (4R,5S,1'S)-4-benzyloxy-1-(N-butyloxycarbonylprolyl)-5-methylpyrrolidin-2-one
• Synonyms: (4R,5S,1'S)-4-benzyloxy-1-(N-butyloxycarbonylprolyl)-5-methylpyrrolidin-2-one
• CAS NO: 1241920-88-6
• Molecular Weight: 402.491
• Mol File: 1241920-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S,1'S)-4-benzyloxy-1-(N-butyloxycarbonylprolyl)-5-methylpyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S,1'S)-4-benzyloxy-1-(N-butyloxycarbonylprolyl)-5-methylpyrrolidin-2-one(1241920-88-6)
• EPA Substance Registry System: (4R,5S,1'S)-4-benzyloxy-1-(N-butyloxycarbonylprolyl)-5-methylpyrrolidin-2-one(1241920-88-6)

Safety Data

• Hazardous Substances Data: 1241920-88-6(Hazardous Substances Data)

Upstream product

• 1241920-77-3 (4R,5S)-4-benzyloxy-5-methylpyrrolidin-2-one 
• 50903-52-1 (tert-butoxycarbonyl)-L-proline pentafluorophenol ester 

Relevant articles and documents

N-Benzyloxymalimide for an easy access to 5-alkyl-3-pyrrolin-2-ones: Asymmetric synthesis of the mixed imide substructure of the potent immunosuppressant microcolin B

O-Benzyl-N-benzyloxymalimide 12 has been synthesized as a useful variant of the chiral building blocks 9. The advantage of the malimide 12 over 9 was demonstrated by mild and high-yielding reductive N-deprotection of N-benzyloxylactams 18a-i to give a series of (4R,5S)-5-alkyl-4-hydroxy- pyrrolidin-2-ones, which are key intermediates for the asymmetric synthesis of pyrrolidines, pyrrolizidines, and indolizidines, as well as β-hydroxy γ-amino acids. Lactam ent-11a has been applied to the synthesis of the mixed imide 25, a key intermediate for the total synthesis of microcolin B, which also demonstrated that lactam ent-11a or 11a can serve as a latent form of the 5-methyl-3-pyrrolin-2-one substructure of majusculamide D 4, deoxymajusculamide D, and the jamaicamides A-C.