1242069-61-9

Basic information

• Product Name: (S)-benzyl (1-hydroxy-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-yl)carbamate
• Synonyms: (S)-benzyl (1-hydroxy-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-yl)carbamate
• CAS NO: 1242069-61-9
• Molecular Weight: 427.383
• Mol File: 1242069-61-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-benzyl (1-hydroxy-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-benzyl (1-hydroxy-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-yl)carbamate(1242069-61-9)
• EPA Substance Registry System: (S)-benzyl (1-hydroxy-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-yl)carbamate(1242069-61-9)

Safety Data

• Hazardous Substances Data: 1242069-61-9(Hazardous Substances Data)

Upstream product

• 87219-29-2 benzyl (3S)-5-oxotetrahydro-3-furanylcarbamate 
• 486460-21-3 3-trifluoromethyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine 

Downstream Products

• 1242069-64-2 (S)-2-(benzyloxycarbonylamino)-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butyl methanesulfonate 
• 1242069-62-0 (S)-benzyl 1-iodo-4-oxo-4-(3-(trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazin-7-yl)butan-2-ylcarbamate 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF A CHIRAL BETA AMINOACID DERIVATIVE AND INTERMEDIATES THEREOF

It comprises a process for the preparation of sitagliptin, or its pharmaceutically acceptable salts, or its solvates, including hydrates, comprising: a) coupling an halo-2,4,5-trifluorobenzene with a compound of formula (IV) to give N-protected sitagliptin; the coupling being carried out via the formation of an organocupric compound of the halo-2,4,5-trifluorobenzene or, alternatively, via the formation of a organozinc compound of a compound of formula (IV); where R1 is hydrogen or an amino protective group; R2 is an amino protective group; or alternatively R1 and R2 taken together form a phtalimido group; X is Br or I; and Y is Br, I or R3SO3- wherein R3 is (C1-C4)- alkyl, phenyl, or phenyl mono- or disubstituted by a (C1-C4)-alkyl radical; b) submitting the N-protected sitagliptin to a deprotection reaction; and c) optionally its conversion into a pharmaceutically acceptable salt. It also comprises new intermediate compounds useful in such preparation process.