1242144-21-3

Basic information

• Product Name: (2S,3S,4R)-2-hydroxy-3,4-O-isopropylideneoctadecyl 2,3,4-tri-O-benzyl-6-O-methyl-α-D-galactopyranoside
• Synonyms: (2S,3S,4R)-2-hydroxy-3,4-O-isopropylideneoctadecyl 2,3,4-tri-O-benzyl-6-O-methyl-α-D-galactopyranoside
• CAS NO: 1242144-21-3
• Molecular Weight: 805.105
• Mol File: 1242144-21-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,3S,4R)-2-hydroxy-3,4-O-isopropylideneoctadecyl 2,3,4-tri-O-benzyl-6-O-methyl-α-D-galactopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S,4R)-2-hydroxy-3,4-O-isopropylideneoctadecyl 2,3,4-tri-O-benzyl-6-O-methyl-α-D-galactopyranoside(1242144-21-3)
• EPA Substance Registry System: (2S,3S,4R)-2-hydroxy-3,4-O-isopropylideneoctadecyl 2,3,4-tri-O-benzyl-6-O-methyl-α-D-galactopyranoside(1242144-21-3)

Safety Data

• Hazardous Substances Data: 1242144-21-3(Hazardous Substances Data)

Upstream product

• 1215176-71-8 trichloroacetoimidoyl 2,3,4-tri-O-benzyl-6-O-methyl-α,β-D-galactopyranoside 
• 175522-91-5 (2S,3S,4R)-3,4-O-isopropylideneoctadecan-1,2-diol 

Downstream Products

• 1242144-25-7 (2S,3R,4R)-2-hexacosanoyloxy-3,4-O-isopropylideneoctadecyl 2,3,4-tri-O-benzyl-6-O-methyl-α-D-galactopyranoside 

Relevant articles and documents

Synthesis and biological activity of ester and ether analogues of α-galactosylceramide (KRN7000)

These three ester analogues showed activity for IFNγ, and IL-4 production of iNKT cells. α-Galactosylceramide (αGalCer, KRN7000) has been identified as a modulator of immunological processes through its capacity to bind iNKT cells mediated by CD1d molecules. Some analogues in while the amide group in αGalCer is replaced with ester or ether groups were synthesized from d-arabinitol or l-ribose to evaluate their ability to activate iNKT cells. Ester analogues 30a, 31a, and 61 showed activity for IFNγ and IL-4 production of iNKT cells, while ether (31b) and 4-methoxy ester (76) analogues of α-galactosylceramide were not active for iNKT cells.