1242175-34-3 Usage
Description
Aprepitant, also known as (2R,3R,1’S)-Aprepitant, is a novel selective neurokinin-1 (NK-1) receptor antagonist. It is an impurity of Aprepitant (A729800) and is primarily metabolized by the CYP3A4 enzyme, with minor metabolism by CYP1A2 and CYP2C19. Aprepitant does not undergo metabolism by CYP2D6, CYP2C9, or CYP2E1. It is a promising pharmaceutical candidate with potential applications in various medical fields.
Uses
Used in Pharmaceutical Industry:
Aprepitant is used as an antiemetic agent for the treatment of nausea and vomiting associated with chemotherapy, radiotherapy, and postoperative recovery. It works by blocking the action of substance P on the NK-1 receptors, which helps in reducing the emesis response.
Used in Oncology:
Aprepitant is used as an antiemetic agent in oncology for the management of chemotherapy-induced nausea and vomiting (CINV). It is particularly effective in preventing acute and delayed emesis caused by highly emetogenic chemotherapy agents.
Used in Radiotherapy:
Aprepitant is used as an antiemetic agent in radiotherapy to help manage the nausea and vomiting that may occur as a side effect of radiation treatments.
Used in Postoperative Recovery:
Aprepitant is used as an antiemetic agent in postoperative recovery to alleviate nausea and vomiting that can occur after surgery, improving patient comfort and recovery time.
Check Digit Verification of cas no
The CAS Registry Mumber 1242175-34-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,2,1,7 and 5 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1242175-34:
(9*1)+(8*2)+(7*4)+(6*2)+(5*1)+(4*7)+(3*5)+(2*3)+(1*4)=123
123 % 10 = 3
So 1242175-34-3 is a valid CAS Registry Number.
1242175-34-3Relevant articles and documents
Synthesis of all enantiomerically pure diastereomers of aprepitant
Gangula, Srinivas,Elati, Chandrashekhar R.,Mudunuru, Satish Varma,Nardela, Anitha,Dongamanti, Ashok,Bhattacharya, Apurba,Bandichhor, Rakeshwar
experimental part, p. 2254 - 2268 (2010/09/11)
Syntheses of all eight enantiomerically pure diastereomers of aprepitant and assignment of absolute configuration at newly generated stereocenters by NMR and X-ray crystallographic analysis were achieved. Copyrigh
