1242336-94-2Relevant articles and documents
Chemoselectivity of cobalt-catalysed carbonylation-A reliable platform for the synthesis of fluorinated benzoic acids
Boyarskiy, Vadim P.,Fonari, Marina S.,Khaybulova, Tatiana S.,Gdaniec, Maria,Simonov, Yurii A.
, p. 81 - 85 (2010)
The cobalt-catalysed methoxycarbonylation of polysubstituted bromo,fluoro- and chloro,fluorobenzenes and 1,2,4-trichlorobenzene with emphasis on the chemo- and regio-selectivity of the reaction is described. The structures of isolated products of 1,4-dichloro-2-fluorobenzene carbonylation were determined by single-crystal X-ray diffraction. The fact that the fluorine substituents in the studied compounds remain intact indicates in favor of the anion-radical activation of aryl halides by a cobalt catalyst. For the first time, a universal method of preparation of the various fluorobenzoic acid derivatives from available raw materials with a good yield has been elaborated.
Preparation method of dicamba
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Paragraph 0014-0019, (2019/01/23)
The invention relates to a preparation method of dicamba. The method comprises the following steps: preparing 2, 5-dichlorobenzoic acid as a starting raw material; further esterifying with methyl alcohol in an acidic condition; processing to obtain a product; further substituting with bromine under the effect of aluminum tribromide; reacting the obtained product with methyl alcohol under the effect of a catalyst; processing; and further hydrolyzing the obtained product to obtain the final product, namely dicamba. Compared with a traditional synthesizing method, the method has the advantages that few synthesizing steps are performed; the reaction process is simple; the reaction temperature is low; the operation safety is improved; the reaction processing in each step is simple, so that thereaction can be conveniently carried out; and the yield is high.
Electroreduction of organic compounds, 36 [1]. Electroreduction of chlorinated methyl benzoates
Gassmann, Joerg,Voss, Juergen
experimental part, p. 1291 - 1299 (2009/06/19)
The preparative electroreduction of the three methyl monochlorobenzoates, the six methyl dichlorobenzoates, and methyl 2,3,4-trichlorobenzoate in different solvent-supporting electrolytes (SSE) was studied. The rate of the dechlorination, which is the main reaction, is dependent on the substitution pattern. Pronounced regioselectivity is therefore observed in case of the oligochloro derivatives. Hydrogenation of the benzene ring and reduction of the methoxycarbonyl group with formation of a hydroxymethyl group are observed as side-reactions. Quantum chemical calculations on the reaction mechanism were performed. The theoretical results are in accordance with the experimental observations.
