124269-04-1 Usage
Description
4-Azaspiro[2.5]octane is a heterocyclic compound featuring a nitrogen atom incorporated into a spiro-octan ring structure. It is a versatile intermediate in organic synthesis and possesses unique structural properties that make it valuable in the development of pharmaceuticals and other chemical applications.
Uses
Used in Pharmaceutical Industry:
4-Azaspiro[2.5]octane is used as a reactant for the preparation of 8-aminomethyltetracyclines, which are known for their potent antibacterial activity. This application is crucial in the development of new antibiotics to combat resistant bacterial strains and improve treatment options for various infections.
Check Digit Verification of cas no
The CAS Registry Mumber 124269-04-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,2,6 and 9 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 124269-04:
(8*1)+(7*2)+(6*4)+(5*2)+(4*6)+(3*9)+(2*0)+(1*4)=111
111 % 10 = 1
So 124269-04-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H13N/c1-2-6-8-7(3-1)4-5-7/h8H,1-6H2
124269-04-1Relevant articles and documents
Utilization of BozPhos as an Effective Ligand in Enantioselective C-H Functionalization of Cyclopropanes: Synthesis of Dihydroisoquinolones and Dihydroquinolones
Mayer, Camilla,Ladd, Carolyn L.,Charette, André B.
, p. 2639 - 2644 (2019)
The bisphosphine monoxide (R,R)-BozPhos enables enantioselective C-H functionalization of cyclopropanes in a palladium-catalyzed cyclization. The synthesis of a broad spectrum of dihydroisoquinolones and dihydroquinolones in good yields and high enantiomeric excess was achieved through the use of this hemilabile ligand. Furthermore, the isolation of an intermediary palladium(II)-BozPhos complex after oxidative addition was successful and a second complex provided further insight into bond length and angles through a crystal structure.
