1242712-29-3

Basic information

• Product Name: 5-(4-methoxyphenyl)-UDP-Gal
• Synonyms: 5-(4-methoxyphenyl)-UDP-Gal
• CAS NO: 1242712-29-3
• Molecular Weight: 672.43
• Mol File: 1242712-29-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(4-methoxyphenyl)-UDP-Gal(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methoxyphenyl)-UDP-Gal(1242712-29-3)
• EPA Substance Registry System: 5-(4-methoxyphenyl)-UDP-Gal(1242712-29-3)

Safety Data

• Hazardous Substances Data: 1242712-29-3(Hazardous Substances Data)

Upstream product

• 1300529-55-8 5-(4-methoxyphenyl)uridine-5′-triphosphate 
• 59-56-3 α-D-galactose-1-phosphate 
• 1253736-62-7 5-iodouridine-5'-diphosphate-α-D-galactose 
• 5720-07-0 4-methoxyphenylboronic acid 

Relevant articles and documents

Enzymatic synthesis of nucleobase-modified UDP-sugars: Scope and limitations

Glucose-1-phosphate uridylyltransferase in conjunction with UDP-glucose pyrophosphorylase was found to catalyse the conversion of a range of 5-substituted UTP derivatives into the corresponding UDP-galactose derivatives in poor yield. Notably the 5-iodo derivative was not converted to UDP-sugar. In contrast, UDP-glucose pyrophosphorylase in conjunction with inorganic pyrophosphatase was particularly effective at converting 5-substituted UTP derivatives, including the iodo compound, into a range of gluco-configured 5-substituted UDP-sugar derivatives in good yields. Attempts to effect 4″-epimerization of these 5-substituted UDP-glucose with UDP-glucose 4″-epimerase from yeast were unsuccessful, while use of the corresponding enzyme from Erwinia amylovora resulted in efficient epimerization of only 5-iodo-UDP-Glc, but not the corresponding 5-aryl derivatives, to give 5-iodo-UDP-Gal. Given the established potential for Pd-mediated cross-coupling of 5-iodo-UDP-sugars, this provides convenient access to the galacto-configured 5-substituted-UDP-sugars from gluco-configured substrates and 5-iodo-UTP.