124281-55-6

Basic information

• Product Name: 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone
• Synonyms: 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone
• CAS NO: 124281-55-6
• Molecular Weight: 318.326
• Mol File: 124281-55-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone(CAS DataBase Reference)
• NIST Chemistry Reference: 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone(124281-55-6)
• EPA Substance Registry System: 2',4',6'-Trihydroxy-3,4-dimethoxydihydrochalcone(124281-55-6)

Safety Data

• Hazardous Substances Data: 124281-55-6(Hazardous Substances Data)

Upstream product

• 480-66-0 2,4,6-trihydroxyacetophenone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 18065-05-9 1-[2,4-bis(benzyloxy)-6-hydroxyphenyl]ethanone 
• 120979-98-8 4',6'-Dibenzyloxy-2'-hydroxy-3,4-dimethoxychalcone 
• 4712-12-3 5,7-dihydroxy-3',4'-dimethoxy flavone 

Downstream Products

• 124281-56-7 5,7-Dihydroxy-3-(3,4-dimethoxybenzyl)chromone 

Relevant articles and documents

New homoisoflavonoid analogues protect cells by regulating autophagy

As a special group of naturally occurring flavonoids, homoisoflavonoids have been discovered as active components of several traditional Chinese medicines for nourishing heart and mind. In this study, twenty homoisoflavonoid analogues, including different substitution groups on rings A and B, as well as heteroaromatic B ring, were synthesized and evaluated for their cardioprotective and neuroprotective activities. In a H2O2-induced H9c2 cardiomyocytes injury assay, nine homoisoflavonoid analogues showed promising activities in the same level as the positive control, diazoxide. Six cardioprotective compounds with representative structure diversities were then evaluated for their neuroprotective effects on MPP+ induced SH-SY5Y cell injury model. Furthermore, autophagy inducing monodansylcadaverine (MDC) fluorescence staining methods and molecular docking studies indicated the action mechanism of these compounds may involve autophagy regulating via class I PI3K signaling pathway.