1242840-80-7

Basic information

• Product Name: 5-(2-nitro-4,5-diMethylphenyl)-2-furaldehyde
• Synonyms: 5-(2-nitro-4,5-diMethylphenyl)-2-furaldehyde
• CAS NO: 1242840-80-7
• Molecular Formula: C₁₃H₁₁NO₄
• Molecular Weight: 245.23074
• EINECS: -0
• Mol File: 1242840-80-7.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(2-nitro-4,5-diMethylphenyl)-2-furaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-nitro-4,5-diMethylphenyl)-2-furaldehyde(1242840-80-7)
• EPA Substance Registry System: 5-(2-nitro-4,5-diMethylphenyl)-2-furaldehyde(1242840-80-7)

Safety Data

• Hazardous Substances Data: 1242840-80-7(Hazardous Substances Data)

Upstream product

• 27329-70-0 5-formylfurane-2-boronic acid 
• 6972-71-0 4,5-dimethyl-2-nitrobenzenamine 
• 88-14-2 2-furanoic acid 
• 1270120-16-5 5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-carboxylic acid 
• 53938-24-2 1-bromo-4,5-dimethyl-2-nitrobenzene 
• 99-51-4 4-nitro-o-xylene 

Downstream Products

• 1270120-29-0 C₂₅H₂₁N₃O₆ 
• 328968-37-2 C₂₄H₁₉N₃O₆ 
• 863230-72-2 C₂₄H₂₀N₄O₅ 
• 1270120-21-2 C₂₄H₁₉ClN₄O₅ 
• 1270120-36-9 C₂₅H₂₂N₄O₅ 
• 441782-66-7 C₂₃H₂₀N₄O₆S 
• 442651-05-0 C₂₃H₁₉N₃O₇S 
• 1270120-28-9 C₂₅H₂₁N₃O₆ 
• 331002-70-1 2-chloro-5-{5-[5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-ylmethylene]-4-oxo-thiazolidin-2-ylideneamino}-benzoic acid 
• 1428422-57-4 3-{5-[5-(4,5-dimethyl-2-nitro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-benzoic acid 

Relevant articles and documents

Histone acetyltransferase P300 small molecule inhibitor and medicinal composition and application thereof

The compound capable of inhibiting histone acetyltransferase, has a significant inhibition effect p300 in inhibiting the activity, of the histone acetyltransferase, or a pharmaceutically acceptable salt (I) of; has a significant inhibitory effect on tumor cells such as the primary, representative small molecule inhibitor p300 to prostate cancer cells, malignant blood tumor cells p300 breast cancer cells, and has an effect of inhibiting the toxicity C646, of the compound by overcoming the defects, of the original, small molecule inhibitor, existing in the present invention. C646 p300. The compounds of the formula C646; are shown in, Table (I). The invention belongs to, the field of pharmaceutical chemistry.

Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitor

The histone acetyltransferase (HAT) p300/CBP is a transcriptional coactivator implicated in many gene regulatory pathways and protein acetylation events. Although p300 inhibitors have been reported, a potent, selective, and readily available active-sitedirected small molecule inhibitor is not yet known. Here we use a structure-based, in silico screening approach to identify a commercially available pyrazolone- containing small molecule p300 HAT inhibitor, C646. C646 is a competitive p300 inhibitor with a Ki of 400 nM and is selective versus other acetyltransferases. Studies on site-directed p300 HAT mutants and synthetic modifications of C646 confirm the importance of predicted interactions in conferring potency. Inhibition of histone acetylation and cell growth by C646 in cells validate its utility as a pharmacologic probe and suggest that p300/CBP HAT is a worthy anticancer target.