124289-21-0

Basic information

• Product Name: 3-BROMO-5-METHYLBENZONITRILE
• Synonyms: 3-BROMO-5-METHYLBENZONITRILE;3-Methyl-5-bromobenzonitrile;3-BroMo-5-Methylbenzonitrile, 95+%;Benzonitrile,3-bromo-5-methyl-;Bromo-5-methyl-benzonitrile
• CAS NO: 124289-21-0
• Molecular Formula: C₈H₆BrN
• Molecular Weight: 196.04
• Mol File: 124289-21-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 57-58.5℃
• Boiling Point: 256.1±20.0℃ (760 Torr)
• Flash Point: 108.7±21.8℃
• Appearance: /
• Density: 1.51±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-BROMO-5-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-METHYLBENZONITRILE(124289-21-0)
• EPA Substance Registry System: 3-BROMO-5-METHYLBENZONITRILE(124289-21-0)

Safety Data

• Hazardous Substances Data: 124289-21-0(Hazardous Substances Data)

Usage

Description

3-Bromo-5-methylbenzonitrile is an organic compound characterized by the presence of a bromo and a methyl group attached to a benzene ring, with a nitrile functional group. It is a versatile intermediate in organic synthesis, known for its unique structural features that facilitate specific chemical reactions.

Uses

Used in Pharmaceutical Industry:
3-Bromo-5-methylbenzonitrile is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique structure allows for the creation of new drug candidates with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 3-Bromo-5-methylbenzonitrile serves as a valuable compound for studying reaction mechanisms and exploring new synthetic pathways. Its reactivity and structural features make it an interesting subject for academic and industrial research.
Used in Material Science:
3-Bromo-5-methylbenzonitrile is utilized in the synthesis of arenes with high steric regiocontrol, which are essential in the development of advanced materials with specific properties. Its use in this context contributes to the advancement of material science and the creation of innovative products.
Used in Agrochemical Industry:
3-BROMO-5-METHYLBENZONITRILE also finds application in the agrochemical industry, where it is employed as a building block for the synthesis of various agrochemicals. Its role in this industry is crucial for the development of new pesticides and other agrochemical products that can improve crop yields and protect plants from pests.

InChI:InChI=1/C8H6BrN/c1-6-2-7(5-10)4-8(9)3-6/h2-4H,1H3

Upstream product

• 58530-13-5 3-bromo-5-methyl-benzoic acid 
• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 13091-43-5 2-amino-3-bromo-5-methylbenzoic acid 
• 1611-92-3 3,5-dibromotoluene 
• 141-78-6 ethyl acetate 
• 544-92-3 copper(I) cyanide 
• 1007578-82-6 3-bromo-5-methylbenzamide 
• 1205515-03-2 3-bromo-5-methylbenzaldehyde oxime 
• 557-21-1 zinc(II) cyanide 
• 942069-53-6 2-(3-bromo-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 591-17-3 meta-bromotoluene 
• 556-96-7 5-bromo-1,3-xylene 
• 51719-69-8 1-bromo-3-(bromomethyl)-5-methylbenzene 
• 648439-19-4 (3-bromo-5-methylphenyl)methanol 

Downstream Products

• 124289-24-3 α-Bromo-3-bromo-5-cyanotoluene 
• 1383983-58-1 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile 
• 1395093-32-9 3-bromo-N-(2,6-diisopropylphenyl)-5-methylbenziimidamide 
• 1395093-33-0 2-(3-bromo-5-methyl)-1-(2,6-diisopropylphenyl)-1H-imidazole 
• 1395093-34-1 2,2'-(oxybis(3-methyl-5,1-phenylene))bis(1-(2,6-diisopropylphenyl)-1H-imidazole) 
• 1177558-49-4 3-bromo-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile 
• 1177558-50-7 3-(aminomethyl)-5-bromobenzonitrile 
• 1177558-71-2 tert-butyl (3-bromo-5-cyanobenzyl)carbamate 
• 1451391-42-6 (3-cyano-5-methylphenyl)boronic acid 

Relevant articles and documents

INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES

Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.

Palladium(II)-catalyzed direct conversion of methyl arenes into aromatic nitriles

From methyl to nitrile: A mild ammoxidation method, which directly converts methyl arenes into aromatic nitriles, has been developed by using Pd(OAc) 2 and N-hydroxyphthalimide (NHPI) as the catalysts, and tert-butyl nitrite as the nitrogen source and oxidant. Copyright

Compounds and their use as BACE Inhibitors

The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.