124338-73-4

Basic information

• Product Name: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(4-ethyl-1-piperazinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-
• Synonyms: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(4-ethyl-1-piperazinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (?à)-; DR 3862
• CAS NO: 124338-73-4
• Molecular Formula: C19H22 F N3 O4
• Mol File: 124338-73-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(4-ethyl-1-piperazinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(4-ethyl-1-piperazinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-(124338-73-4)
• EPA Substance Registry System: 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicacid, 10-(4-ethyl-1-piperazinyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-(124338-73-4)

Safety Data

• Hazardous Substances Data: 124338-73-4(Hazardous Substances Data)

Upstream product

• 5308-25-8 4-ethylpiperazine 
• 82419-35-0 9,10-difluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]-benzoxazine-6-carboxylic acid 
• 771-69-7 2,3,4-trifluoronitrobenzene 
• 82419-32-7 3,4-difluoro-2-(2-oxopropyloxy)nitrobenzene 
• 82419-26-9 2,3-difluoro-6-nitrophenol 
• 82419-34-9 ethyl 9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylate 
• 82419-33-8 (-)-7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine 
• 86760-99-8 diethyl [(-)-7,8-difluoro-3-methyl-2,3-dihydro-4H-[1,4]benzoxazin-4-yl]methylenemalonate 

Relevant articles and documents

Synthesis and antibacterial activities of substituted 7-oxo-2,3-dihydro-7h-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids

As part of a search for new synthetic antibacterial agents to combat systemic infection, various analogues of 7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids were synthesized. Among the compounds newly synthesized, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[ 1,2,3-de][1,4]benzoxazine-6-carboxylic acid (DL-8280) showed potent antibacterial activity against Gram-positive and -negative pathogens, including Psedomonas aeruginosa, and its metabolic disposition was shown in separate experimentals to be favorable.