124339-42-0

Basic information

• Product Name: (Z)-(S)-<1-(phenylmethyl)-5-(trimethylsilyl)-3-hexen-5-ynyl>carbamic acid 1,1-dimethylethyl ester
• CAS NO: 124339-42-0
• Molecular Weight: 343.541
• Mol File: 124339-42-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (Z)-(S)-<1-(phenylmethyl)-5-(trimethylsilyl)-3-hexen-5-ynyl>carbamic acid 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-(S)-<1-(phenylmethyl)-5-(trimethylsilyl)-3-hexen-5-ynyl>carbamic acid 1,1-dimethylethyl ester(124339-42-0)
• EPA Substance Registry System: (Z)-(S)-<1-(phenylmethyl)-5-(trimethylsilyl)-3-hexen-5-ynyl>carbamic acid 1,1-dimethylethyl ester(124339-42-0)

Safety Data

• Hazardous Substances Data: 124339-42-0(Hazardous Substances Data)

Upstream product

• 87694-53-9 Boc-Phe-OH N,O-dimethyl hydroxamate 
• 42134-49-6 (3-trimethylsilyl-2-propynyl)triphenylphosphonium bromide 
• 72155-45-4 Boc-L-phenylalaninal 

Downstream Products

• 76175-13-8 (Z)-(S)-5-tert-Butoxycarbonylamino-6-phenyl-hex-3-enoic acid 
• 118404-83-4 Boc-PheΨGly-Sta-Leu-NHCH2Ph 
• 118404-89-0 {(S)-1-[3-({(S)-1-[(S)-2-((S)-1-Benzylcarbamoyl-3-methyl-butylcarbamoyl)-1-hydroxy-ethyl]-3-methyl-butylcarbamoyl}-methyl)-oxiranyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: Probing the requirements for Alzheimer's amyloidogenesis

Herein, we report a stereospecific E-olefin dipeptide isostere synthesis that can be used to make gram quantities of the Phe-Phe isostere desired for eliminating a specific backbone H-bond donor and acceptor in the Alzheimer's disease related Aβ peptide.

Renin inhibitors containing isosteric replacements of the amide bond connecting the P3 and P2 sites

Renin inhibitors having 13 different isosteres connecting the P3 and P2 positions have been prepared. Synthetic routes and in vitro activity exhibited by these compounds are discussed. The two most potent compounds, 47 and 48, contai