1243391-44-7 Usage
Description
RofluMilast related substance is a degradation product of RofluMilast, which is a phosphodiesterase-4 (PDE4) inhibitor used in the treatment of chronic obstructive pulmonary disease (COPD). It is characterized by its chemical structure, which is derived from 3-(cyclopropylmethoxy)-4-hydroxybenzoic acid.
Uses
Used in Pharmaceutical Industry:
RofluMilast related substance is used as an impurity in the production and quality control of RofluMilast, a drug used for the treatment of COPD. The presence of this related substance is important to monitor and control, as it can affect the safety, efficacy, and quality of the final drug product.
Used in Research and Development:
RofluMilast related substance can be used as a research compound for studying the degradation pathways of RofluMilast and understanding its stability under various conditions. This information can be valuable for optimizing the drug's formulation, shelf life, and overall performance.
Used in Quality Control and Regulatory Compliance:
RofluMilast related substance is used as a reference material in the development and validation of analytical methods for the quantification of impurities in RofluMilast drug products. This helps ensure that the drug meets the required quality standards and regulatory guidelines for safety and efficacy.
Check Digit Verification of cas no
The CAS Registry Mumber 1243391-44-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,3,3,9 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1243391-44:
(9*1)+(8*2)+(7*4)+(6*3)+(5*3)+(4*9)+(3*1)+(2*4)+(1*4)=137
137 % 10 = 7
So 1243391-44-7 is a valid CAS Registry Number.
1243391-44-7Relevant articles and documents
A new route to Roflumilast via copper-catalyzed hydroxylation
Ni, Feng,Li, Jianqi
, p. 3598 - 3602 (2013/02/22)
A new route to Roflumilast, a selective phosphodiesterase type 4 (PDE 4) inhibitor, is described. The synthetic procedure starts from 4-hydroxy-3-iodobenzoic acid to access the key intermediate 3- (cyclopropylmethoxy)-4-(difluoromethoxy)benzoic acid via copper-catalyzed hydroxylation and utilizes amide coupling to accomplish the synthesis of Roflumilast in 80% overall yield. Georg Thieme Verlag KG Stuttgart · New York.
