124351-85-5 Usage
Description
Incadronic, also known as Bisphonal, is a third-generation bisphosphonate derivative used primarily for the treatment of osteoporosis. It is prepared through a two-step process involving the heating of cycloheptylamine, triethylorthoformate, and diethyl phosphite, followed by ester hydrolysis. The drug's mechanism of action is not entirely understood, but it is known to tightly bind to the calcified bone matrix, inhibiting bone resorption without affecting bone mineralization. Incadronic causes a decrease in the number and activity of osteoclasts, leading to cell death and an impairment in osteoclast formation. It does not induce osteomalacia and its activity is partly mediated through osteoblasts, which release an inhibitor of osteoclast recruitment. Additionally, Incadronic is a potent inhibitor of squalene synthase, possibly through Mg2+ chelation or as a pyrophosphate mimic, and it stimulates renal production of 1,25-dihydroxyvitamin D with minimal metabolism.
Uses
Used in Pharmaceutical Industry:
Incadronic is used as an osteoporosis treatment for [application reason] managing bone loss and improving bone density in patients. It works by inhibiting bone resorption and decreasing the number and activity of osteoclasts, leading to an overall improvement in bone health.
Used in Anticancer Applications:
Although not explicitly mentioned in the provided materials, bisphosphonates like Incadronic have been explored for their potential use in cancer treatment, particularly in managing bone metastases and reducing the risk of skeletal-related events in patients with advanced cancer.
Used in Agricultural Industry:
Incadronic, as a bisphosphonate derivative, is also used as a herbicide for [application reason] controlling the growth of unwanted plants and promoting the health of desired crops.
Used in Veterinary Medicine:
Incadronic may be used as an antiparasitic agent in veterinary medicine for [application reason] treating and preventing parasitic infections in animals, contributing to their overall health and well-being.
Originator
Yamanouchi (Japan)
Check Digit Verification of cas no
The CAS Registry Mumber 124351-85-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,3,5 and 1 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 124351-85:
(8*1)+(7*2)+(6*4)+(5*3)+(4*5)+(3*1)+(2*8)+(1*5)=105
105 % 10 = 5
So 124351-85-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H19NO6P2/c10-16(11,12)8(17(13,14)15)9-7-5-3-1-2-4-6-7/h7-9H,1-6H2,(H2,10,11,12)(H2,13,14,15)
