1243634-78-7

Basic information

• Product Name: (-)-methyl (1R,2R,3S,5S)-1-propyl-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
• Synonyms: (-)-methyl (1R,2R,3S,5S)-1-propyl-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
• CAS NO: 1243634-78-7
• Molecular Weight: 345.439
• Mol File: 1243634-78-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (-)-methyl (1R,2R,3S,5S)-1-propyl-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-methyl (1R,2R,3S,5S)-1-propyl-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate(1243634-78-7)
• EPA Substance Registry System: (-)-methyl (1R,2R,3S,5S)-1-propyl-3-(benzoyloxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate(1243634-78-7)

Safety Data

• Hazardous Substances Data: 1243634-78-7(Hazardous Substances Data)

Upstream product

• 1243634-77-6 (+)-methyl (1R,2R,3S,5S)-1-propyl-3-(hydroxy)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate methanesulfonic acid salt 
• 98-88-4 benzoyl chloride 
• 105-21-5 4-propylbutanolide 
• 1243634-66-3 (S(S),3S)-(+)-N-(p-toluenesulfinyl)-3-amino-5-(2-propyl-1,3-dioxolan-2-yl)pentanal 
• 41221-88-9 3-(2-propyl-1,3-dioxolan-2-yl)propanal 
• 1360562-59-9 4-hydroxy-N-methoxy-N-methylheptanamide 
• 1243634-68-5 (Ss,5S,2E)-(+)-methyl N-(p-toluenesulfinyl)-5-amino-7-(2-propyl-1,3-dioxolan-2-yl)-hept-2-enoate 
• 1243634-69-6 (5S,2E)-(+)-methyl (3,4-dihydro-5-propyl-2H-pyrrol-2-yl)-but-2-enoate 
• 1243634-70-9 C₁₂H₁₉NO₃ 
• 1360562-65-7 N-methoxy-N-methyl-3-(2-propyl-1,3-dioxolan-2-yl)propanamide 

Relevant articles and documents

COCAINE ANALOGS AND METHODS OF PREPARATION AND USES THEREOF

The invention provides novel cocaine analogs. The invention also provides a method of preparing cocaine analogs with control over the substituents installed at the C-1, C-2, C-3, C-4 and N-8 positions of the tropane bicyclic scaffold. The invention further provides a method of providing anesthesia to a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a compound of the invention. The invention also provides a method of blocking reuptake of a monoamine neurotransmitter in a subject in need thereof, to a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a compound of the invention.

Asymmetric total synthesis of (S)-(+)-cocaine and the first synthesis of cocaine C-1 analogs from N -sulfinyl β-amino ester ketals

Sulfinimine-derived α,β-unsaturated pyrrolidine nitrones, on heating with Al(O-t-Bu)3, undergo a highly stereoselective intramolecular [3 + 2] cycloaddition to give tricyclic isoxazolidines, which are transformed in three-steps to give C-1 substituted cocaine analogs.