1243641-72-6

Basic information

• Product Name: C₂₂H₂₆N₄O₃
• CAS NO: 1243641-72-6
• Molecular Weight: 394.473
• Mol File: 1243641-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆N₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆N₄O₃(1243641-72-6)
• EPA Substance Registry System: C₂₂H₂₆N₄O₃(1243641-72-6)

Safety Data

• Hazardous Substances Data: 1243641-72-6(Hazardous Substances Data)

Upstream product

• 4410-12-2 1-benzyl-[1,4]diazepane 
• 496056-82-7 2-chloro-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamide 

Relevant articles and documents

Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3- oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation

Herein we describe the discovery of compound 3g, a potent positive inotropic agent compared with the standard drug, milrinone. Compound 3g was developed from a series of 2-(4-substitutedbenzyl-1,4-diazepan-1-yl)-N-(3,4- dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl) acetamides found in an evaluation of inotropic activity by measuring left atrium stroke volume on isolated rabbit heart preparations. Several compounds showed favorable activities, but 3g was the most potent, with 7.68 ± 0.14% increased stroke volume (milrinone 2.38 ± 0.05%) at 1 × 10-5 M in our in vitro study. The chronotropic effects of compounds having significant inotropic effects were also evaluated.