1243985-65-0Relevant articles and documents
Mechanochemical synthesis of (hetero)aryl Au(i) complexes
Dyrager, Christine,Gates, Paul J.,Giustra, Zachary X.,Ingner, Fredric J. L.,Novosedlik, Sebastian,Orthaber, Andreas,Pilarski, Lukasz T.
supporting information, p. 5648 - 5655 (2020/09/21)
Growing demand for sustainable chemical syntheses casts mechanochemistry in a new light as an environmentally benign alternative to traditional solvent-based methods. Given recent interest in Au(i) complexes for catalytic, materials, and medicinal applications, we developed a mechanochemical protocol to prepare (hetero)aryl Au(i) complexes under green conditions. The procedure reported here uses C-H or C-B activation to afford the corresponding Au(i) complexes in high yields. Our approach bypasses external heating, long reaction times and the use of toxic solvents. We demonstrate that mechanochemical C-H auration can be used on highly functionalised bioactive substrates. Mechanistic aspects of the C-H auration are discussed.
Palladium-catalyzed cross-coupling reactions of organogold(i) phosphanes with allylic electrophiles
Pena-Lopez, Miguel,Ayan-Varela, Miguel,Sarandeses, Luis A.,Sestelo, Jose Perez
, p. 1686 - 1694 (2012/03/22)
Aryl and alkenylgold(i) phosphanes react regioselectively with allylic electrophiles such as cinnamyl and geranyl halides (bromide, chloride and acetates) under palladium catalysis in THF at 80 °C to afford the α-substitution product with moderate to high yields. When the reaction is performed with a chiral enantiopure secondary acetate, the α-substituted cross-coupling product is obtained with complete inversion of the stereochemistry.
