124403-90-3

Basic information

• Product Name: methyl 4-(2-methylpropoxy)benzoate
• Synonyms: methyl 4-(2-methylpropoxy)benzoate
• CAS NO: 124403-90-3
• Molecular Weight: 208.257
• Mol File: 124403-90-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: methyl 4-(2-methylpropoxy)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-methylpropoxy)benzoate(124403-90-3)
• EPA Substance Registry System: methyl 4-(2-methylpropoxy)benzoate(124403-90-3)

Safety Data

• Hazardous Substances Data: 124403-90-3(Hazardous Substances Data)

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 513-36-0 isobutyryl chloride 
• 99-96-7 4-hydroxy-benzoic acid 
• 78-77-3 Isobutyl bromide 
• 78-83-1 2-methyl-propan-1-ol 
• 513-38-2 Isobutyl iodide 

Downstream Products

• 1373823-20-1 4-(2-methylpropoxy)-N-[8-methyl-3-(pyrrolidin-1-ylmethyl)-quinolin-7-yl]benzamide 
• 40782-45-4 4-(2-methylpropoxy)benzoyl chloride 
• 91430-26-1 4-Isobutyloxy-benzoesaeurehydrazid 
• 4734-09-2 1-[4-(2-methylpropyloxy)phenyl]methanamine 
• 1030513-44-0 4-isobutoxybenzamide 
• 706779-91-1 N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide 
• 30762-00-6 4-isobutoxybenzoic acid 

Relevant articles and documents

Identification of new aryl hydrocarbon receptor (AhR) antagonists using a zebrafish model

A new series of 1,3-diketone, heterocyclic and α,β-unsaturated derivatives were synthesized and evaluated for their AhR antagonist activity using zebrafish and mammalian cells. Compounds 1b, 2c, 3b and 5b showed significant AhR antagonist activity in a transgenic zebrafish model. Among them, compound 3b, and 5b were found to have excellent AhR antagonist activity with IC50 of 3.36 nM and 8.3 nM in a luciferase reporter gene assay. In stem cell proliferation assay, compound 5b elicited marked HSC expansion.

Synthesis, Antiproliferative and Antioxidant Activity of 3-Mercapto-1,2,4-Triazole Derivatives as Combretastatin A-4 Analogues

Two series of 3-mercapto-1,2,4-triazole derivatives containing alkoxy substituents different in size and position were synthesized and their structures were characterized by FT-IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. The synthesized compounds were assessed for their antiproliferative activity against colon cancer cell line (SW480). The results indicated that the size and position of the alkoxy group significantly influenced the antiproliferative activity. The highest cancer cell growth inhibition values were observed for the compounds containing 3,4,5-trimethoxyphenyl groups in their structures (57.74, 54.14 and 60.70% at 50 μM for compounds 5a, 12b and 14, respectively). The synthesized compounds were also subjected to DPPH protocol for evaluating the antioxidant activity. The results showed that all compounds had moderate to high levels of antioxidant capacity as compared to ascorbic acid as standard, the highest free radical scavenging capacity of 75% was observed for compound 4a at 50 μM.

Synthetic method of Pimavanserin

The invention belongs to the field of medicine synthesis, and especially relates to a synthetic method of Pimavanserin. According to the synthetic method, 4-hydroxy benzoic acid is taken as a raw material, esterification reaction, alkylation reaction, hydrolysis, acylation reaction, dehydration reduction, and acylation reaction are carried out to obtain an intermediate (9); fluorobenzylamine and N-methyl-4-piperidone are taken as raw materials for reductive amination to obtain intermediate (10); and at last the intermediate (9) and the intermediate (10) are subjected to aminolysis to obtain finished product Pimavanserin. The initial raw materials are cheap and easily available; reaction conditions are mild; no column chromatography is needed; and the yield is relatively high.