124414-37-5Relevant articles and documents
A Chiral, Dendralenic C-H Acid
H?fler, Denis,List, Benjamin
supporting information, p. 38 - 39 (2021/12/29)
We report the synthesis of a chiral dendralenic C H acid, which contains three unsubstituted binaphthyl moieties. This motif and an achiral variant can be made from their corresponding bis(sulfone) precursors in one step. Despite the presence of the enantiopure binaphthyl backbone, the newly designed chiral C H acid showed only poor enantioselectivity in a Mukaiyama aldol reaction. First attempts toward the synthesis of 3,3'-hexasubstituted binaphthyl-based dendralenic acids are also reported.
Method for preparing substituted thiophenol and heterocyclic thiophenol by continuous flow reactor
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Paragraph 0093-0094; 0097-0098, (2019/01/14)
The invention relates to a method for preparing substituted thiophenol and heterocyclic thiophenol by a continuous flow reactor. Phenol and phenol derivatives or heterocyclic phenol are taken as starting materials, and target compounds are prepared by four-step reactions of chlorination, esterification, rearrangement and hydrolysis, wherein the rearrangement reaction is conducted in the continuousflow reactor. According to the method, the reaction is guaranteed by a miniaturized heating device for high-temperature reaction and heat generated by the reaction, the conversion rate and the yieldhigher than those in the conventional reactor are obtained in the short residence time of tens of seconds, relevant side reactions are reduced, meanwhile, fluctuation of temperature and concentrationis avoided in the reaction process, temperature run-away and overheat are avoided, and the reaction process is safe and controllable.
Practical synthetic approach to chiral sulfonimides (CSIs) - Chiral bronsted acids for organocatalysis
He, Hao,Chen, Ling-Yan,Wong, Wai-Yeung,Chan, Wing-Hong,Lee, Albert W. M.
supporting information; experimental part, p. 4181 - 4184 (2010/10/02)
A general approach to the synthesis of optically pure 3,3'diaryl chiral sulfonimides (CSIs) from racemic BINOL has been developed. ortho-Lithiation is directed by the sulfonyl groups, and the resulting dihalides serve as the common precursors for the aryl-substituted CSIs.