124434-84-0Relevant articles and documents
Lessons in Strain and Stability: Enantioselective Synthesis of (+)-[5]-Ladderanoic Acid
Hancock, Erin N.,Kuker, Erin L.,Tantillo, Dean J.,Brown, M. Kevin
supporting information, p. 436 - 441 (2019/11/25)
The synthesis of structurally complex and highly strained natural products provides unique challenges and unexpected opportunities for the development of new reactions and strategies. Herein, the synthesis of (+)-[5]-ladderanoic acid is reported. En route to the target, unusual and unexpected strain release driven transformations were uncovered. This occurrence required a drastic revision of the synthetic design that ultimately led to the development of a novel stepwise cyclobutane assembly by an allylboration/Zweifel olefination sequence.
SYNTHESIS OF SPIROCYCLOPROPANEINDENE PYRETHROIDS
Tolstikov, G. A.,Galin, F. Z.,Ignatyuk, V. K.,Lakeev, S. N.,Berg, A. A.,et al.
, p. 1090 - 1100 (2007/10/02)
A series of alkyl-substituted pyrethroid analogs were synthesized from ethyl 3,3-dialkyl-3'-alkylspiro-2-carboxylates.Cyclopropanation of acetyl- and methoxycarbonylbenzofluvenes, obtained from 1H-indene, by sulfur ylides containing a fragment of the pyrethroid alcohol component, led to compounds not exhibiting insecticidal activity.
