1245469-32-2

Basic information

• Product Name: C₂₂H₂₆N₄O
• CAS NO: 1245469-32-2
• Molecular Weight: 362.475
• Mol File: 1245469-32-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₆N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₆N₄O(1245469-32-2)
• EPA Substance Registry System: C₂₂H₂₆N₄O(1245469-32-2)

Safety Data

• Hazardous Substances Data: 1245469-32-2(Hazardous Substances Data)

Upstream product

• 38212-30-5 4-(4-methoxyphenyl)piperazine 
• 21487-48-9 3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde 

Relevant articles and documents

Smoothened antagonists for hair inhibition

A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened β-lactamase reporter assay and Smoothened binding assay. Potent Smoothened antagonists 10k and 10l were found to inhibit hair growth in vivo in the C3H/HeN mouse hair growth model. The more selective compound 10l was tested negative in the 3T3 NRU assay, indicating a low risk for causing photo-irritation and was efficacious using the C3H/HeN mouse hair growth model although it was slightly less efficacious than that of the reference compound eflornithine (7).