1245469-33-3Relevant articles and documents
Smoothened antagonists for hair inhibition
Li, Jie Jack,Shanmugasundaram, Veerabahu,Reddy, Satya,Fleischer, Laura L.,Wang, Zenquan,Smith, Yvonne,Harter, William G.,Yue, Wen-Song,Swaroop, Manju,Li, Ling,Ji, Christy Xiaodong,Dettling, Danielle,Osak, Bella,Fitzgerald, Laura R.,Conradi, Robert
scheme or table, p. 4932 - 4935 (2010/10/02)
A series of aminomethylpyrazoles were prepared and evaluated using cell-based Smoothened β-lactamase reporter assay and Smoothened binding assay. Potent Smoothened antagonists 10k and 10l were found to inhibit hair growth in vivo in the C3H/HeN mouse hair growth model. The more selective compound 10l was tested negative in the 3T3 NRU assay, indicating a low risk for causing photo-irritation and was efficacious using the C3H/HeN mouse hair growth model although it was slightly less efficacious than that of the reference compound eflornithine (7).