124550-72-7

Basic information

• Product Name: (4R,5R)-4-chloromethyl-5-bis(4-methylphenyl)phosphinomethyl-2,2-dimethyl-1,3-dioxolan
• CAS NO: 124550-72-7
• Molecular Weight: 376.863
• Mol File: 124550-72-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5R)-4-chloromethyl-5-bis(4-methylphenyl)phosphinomethyl-2,2-dimethyl-1,3-dioxolan(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5R)-4-chloromethyl-5-bis(4-methylphenyl)phosphinomethyl-2,2-dimethyl-1,3-dioxolan(124550-72-7)
• EPA Substance Registry System: (4R,5R)-4-chloromethyl-5-bis(4-methylphenyl)phosphinomethyl-2,2-dimethyl-1,3-dioxolan(124550-72-7)

Safety Data

• Hazardous Substances Data: 124550-72-7(Hazardous Substances Data)

Upstream product

• 1017-60-3 di-p-tolylphosphine 
• 69055-79-4 (+)-(2R,3R)-2,3-O-isopropylidene-2,3-dihydroxy-1,4-dichlorobutane 

Downstream Products

• 124550-74-9 (4R,5R)-4-bis(4-methylphenyl)phosphinomethyl-5-bis(4-methoxyphenyl)phosphinomethyl-2,2-dimethyl-1,3-dioxolane 
• 124550-76-1 (4R,5R)-4-bis(4-methylphenyl)phosphinomethyl-5-bis(4-trimethylsilylphenyl)phosphinomethyl-2,2-dimethyl-1,3-dioxolane 

Relevant articles and documents

Asymmetrische katalytische Hydrierung von Acylamino-acrylsaeureethylester und (Z)-Acylamino-zimtsaeuremethylester mit Rhodium-(Diop-Derivat)-Komplexen als Katalysatoren. Einfluss der Einfuehrung zweier Bisarylphosphino-Gruppen mit unterschiedlichen Elektronendichten an den Phosphorato...

(R,R)-Diop was modified by the introduction of two bis-arylphosphino groups of different charge densities on the phosphorus atoms, so that unsymmetrically substituted diop derivatives were formed.The effects of the substituents and the loss of the two-fold rotation axis were examined on the basis of the hydrogenation of ethyl α-acylamino-acrylate (AAEE) and (Z)-methyl α-acylamino-cinnamate (AZME) with +BF4- (ns-Rh) as the catalytic precursor with the least steric influence by the substituents.We reported recently the results of the hydrogenation of the same substrates but with +BF4- (s-Rh) as the catalytic precursor.The electronic and steric effects of the substituents we had found by the hydrogenation experiments with the s-Rh (1) affected the optical yields with the ns-Rh nearly additively.This means that the optical yield obtained with an ns-Rh was fairly consistent with the value calculated by averaging the optical yields of the corresponding s-Rh.Surprisingly the electronic and in special cases the steric features of the substituents are sufficient to explain the results.The loss of the two-fold rotation had no significant effect.The effects of solvation were not examined.