124556-78-1Relevant articles and documents
Regioselective Functionalization of Chlorophthalazine Derivatives
Crestey, Francois,Knochel, Paul
experimental part, p. 1097 - 1106 (2010/06/14)
Chlorophthalazines were efficiently metalated using tmpZnClLiCl under microwave irradiation. This provided novel substituted phthalazine derivatives after subsequent trapping of the resulting organometallic reagents with various electrophiles. Moreover, Negishi cross-coupling reactions have been performed affording new polyfunctionalized phthalazine scaffolds in very good yields.
Development of a practical synthesis of a p38 MAP kinase inhibitor
Thiel, Oliver R.,Achmatowicz, Michal,Bernard, Charles,Wheeler, Philip,Savarin, Cecile,Correll, Tiffany L.,Kasparian, Annie,Allgeier, Alan,Bartberger, Michael D.,Tan, Helming,Larsen, Robert D.
experimental part, p. 230 - 241 (2010/04/22)
A practical synthesis of the phthalazine-based p38 MAP kinase inhibitor [(S)-2] was needed for an ongoing program. Vibrational circular dichroism provided the assignment of the absolute stereochemistry of the target compound. The selected synthetic route
Phthalazine, aza- and diaza-phthalazine compounds and methods of use
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Page/Page column 32, (2008/06/13)
The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.