1245716-73-7Relevant articles and documents
Rational creation of mutant enzyme showing remarkable enhancement of catalytic activity and enantioselectivity toward poor substrates
Ema, Tadashi,Kamata, Shusuke,Takeda, Masahiro,Nakano, Yasuko,Sakai, Takashi
supporting information; experimental part, p. 5440 - 5442 (2010/09/10)
Catalytic activity and enantioselectivity of lipase toward poor substrates bearing bulky substituents on both sides have been dramatically improved by rational design; the E value for a poor substrate was increased from 5 (wild-type enzyme) to >200 (I287F