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1245816-48-1

1245816-48-1

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1245816-48-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1245816-48-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,5,8,1 and 6 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1245816-48:
(9*1)+(8*2)+(7*4)+(6*5)+(5*8)+(4*1)+(3*6)+(2*4)+(1*8)=161
161 % 10 = 1
So 1245816-48-1 is a valid CAS Registry Number.

1245816-48-1Downstream Products

1245816-48-1Relevant articles and documents

Synthesis and biological activity of a series of tetrasubstituted- imidazoles as P2X7 antagonists

Gleave, Robert J.,Walter, Daryl S.,Beswick, Paul J.,Fonfria, Elena,Michel, Anton D.,Roman, Shilina A.,Tang, Sac-Pham

scheme or table, p. 4951 - 4954 (2010/10/04)

A series of analogues of the pyrazole lead 1 were synthesized in which the heterocyclic core was replaced with an imidazole. A number of potent antagonists were identified and structure-activity relationships (SAR) were investigated both with respect to activity at the P2X7 receptor and in vitro metabolic stability. Compound 10 was identified as a potent P2X7 antagonist with reduced in vitro metabolism and high solubility.

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