124583-51-3

Basic information

• Product Name: 4-phenyl-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole
• CAS NO: 124583-51-3
• Molecular Weight: 255.343
• Mol File: 124583-51-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-phenyl-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole(124583-51-3)
• EPA Substance Registry System: 4-phenyl-2-<<4(5)-methyl-5(4)-imidazolyl>methyl>thiazole(124583-51-3)

Safety Data

• Hazardous Substances Data: 124583-51-3(Hazardous Substances Data)

Upstream product

• 51667-66-4 4⁽⁵⁾-(cyanomethyl)-5⁽⁴⁾-methylimidazole 

Relevant articles and documents

Thiazole as a Carbonyl Bioisostere. A Novel Class of Highly Potent and Selective 5-HT3 Receptor Antagonists

A novel structural class of highly potent and selective 5-HT3 receptor antagonists is described.The compounds in this new series contain a thiazole moiety linking an aromatic group and a nitrogen-containing basic region; the thiazole group appears to be acting as a carbonyl bioisostere in this system.An optimized member of this series, 4-(2-methoxyphenyl)-2-methyl>thiazole (5), exhibits oral activity in the Bezold-Jarisch reflex paradigm comparable to or better than the standard agents ondansetron (1) and ICS-205-930 (2).Several of the structure-activity relationships are rationalized in terms of a computer pharmacophore model for 5-HT3 receptor binding.