1245835-34-0Relevant articles and documents
Pyrazolopyridazine alpha-2-delta-1 ligands for the treatment of neuropathic pain
Myatt, James W.,Healy, Mark P.,Bravi, Gianpaolo S.,Billinton, Andrew,Johnson, Christopher N.,Matthews, Kim L.,Jandu, Karamjit S.,Meng, Wenjing,Hersey, Anne,Livermore, David G.,Douault, Clement B.,Witherington, Jason,Bit, Rino A.,Rowedder, James E.,Brown, Jason D.,Clayton, Nick M.
scheme or table, p. 4683 - 4688 (2010/09/18)
Optimization of the novel alpha-2-delta-1 ligand 4 provided compounds 37 and 38 which have improved DMPK profiles, good in vivo analgesic activity and in vitro selectivity over alpha-2-delta-2. An in-house P-gp prediction programme and the MetaSite softwa