1246024-63-4

Basic information

• Product Name: Fmoc(BocApi)OBn
• Synonyms: Fmoc(BocApi)OBn
• CAS NO: 1246024-63-4
• Molecular Weight: 556.659
• Mol File: 1246024-63-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Fmoc(BocApi)OBn(CAS DataBase Reference)
• NIST Chemistry Reference: Fmoc(BocApi)OBn(1246024-63-4)
• EPA Substance Registry System: Fmoc(BocApi)OBn(1246024-63-4)

Safety Data

• Hazardous Substances Data: 1246024-63-4(Hazardous Substances Data)

Upstream product

• 183673-66-7 N-Fmoc-amino-(4-N-Boc-piperidinyl)carboxylic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1246024-64-5 H(BocApi)OBn 
• 1246024-70-3 H(BocApi)4OBn 

Relevant articles and documents

Oligo(4-aminopiperidine-4-carboxylic acid): An unusual basic oligopeptide with an acid-induced helical conformation

In sharp contrast with helical polypeptides carrying basic side chains, Api8, a basic oligopeptide containing the non-natural achiral amino acid 4-aminopiperidine-4-carboxylic acid (Api), adopts a helical conformation only in acidic media. Alkaline titration of a protonated Api8 oligomer appended with a leucine derivative at its N-terminus showed that disruption of its helical conformation occurs in a pH range of 7-10. NMR studies indicated that the piperidine groups in Api8, when nonprotonated, possibly interact with the proximal amide protons in the peptide backbone and hamper the formation of the H-bonding network responsible for the helical conformation. The helical structure is induced not only by protonation but also by acylation of the piperidine groups.