1246196-76-8

Basic information

• Product Name: C₄₅H₅₆O₁₁
• CAS NO: 1246196-76-8
• Molecular Weight: 772.933
• Mol File: 1246196-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₅H₅₆O₁₁(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₅H₅₆O₁₁(1246196-76-8)
• EPA Substance Registry System: C₄₅H₅₆O₁₁(1246196-76-8)

Safety Data

• Hazardous Substances Data: 1246196-76-8(Hazardous Substances Data)

Upstream product

• 930280-13-0 C₃₁H₄₆O₁₀ 
• 86539-99-3 diphenylacetic acid anhydride 

Downstream Products

• 1246196-80-4 C₄₂H₅₂O₁₁ 

Relevant articles and documents

Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase

Removal of each of the acyl groups of thapsigargin at O-3, O-8 and O-10 significant reduces the affinity of the inhibitors to the SERCA1a pump. Replacement of the acyl groups at O-3 and O-10 with flexible residues could be performed with only a minor decrease of the affinity, whereas introduction of voluminous stiff residues caused dramatic reduction of the affinity. The results can be rationalized on the basis of the interactions of thapsigargin with the SERCA1a pump as revealed from 3D X-ray structural models of thapsigargin bound to the SERCA1a. In conclusion the results confirm and elaborate the previously suggested pharmocophore model of thapsigargin.