124622-11-3 Usage
Type of drug
Semisynthetic anthracycline anticancer antibiotic
Origin
Derived from doxorubicin
Lipophilic property
Prodrug that can be incorporated into liposomes for targeted delivery to tumor cells
Activation process
Converted into the active drug, doxorubicin, through enzymatic cleavage of the palmitate moiety within the tumor
Mechanism of action
Intercalates into DNA and inhibits topoisomerase II, leading to DNA damage and cell death
Preclinical studies
Shown promise in improved tumor targeting and reduced cardiotoxicity compared to doxorubicin
Potential applications
Treatment of various cancers
Advantages
Enhanced tumor targeting and lower cardiotoxicity compared to the parent drug, doxorubicin
Check Digit Verification of cas no
The CAS Registry Mumber 124622-11-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,6,2 and 2 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 124622-11:
(8*1)+(7*2)+(6*4)+(5*6)+(4*2)+(3*2)+(2*1)+(1*1)=93
93 % 10 = 3
So 124622-11-3 is a valid CAS Registry Number.
InChI:InChI=1/C43H58O13/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-20-32(46)54-24-31(45)43(52)22-27-35(30(23-43)56-33-21-28(44)38(47)25(2)55-33)42(51)37-36(40(27)49)39(48)26-18-17-19-29(53-3)34(26)41(37)50/h17-19,25,28,30,33,38,44,47,49,51-52H,4-16,20-24H2,1-3H3/t25-,28-,30-,33+,38+,43-/m0/s1
