124623-15-0

Basic information

• Product Name: 2-propionyl-4-bromoaniline
• Synonyms: 2-propionyl-4-bromoaniline;1-(2-amino-5-bromophenyl)propan-1-one
• CAS NO: 124623-15-0
• Molecular Formula: C₉H₁₀BrNO
• Molecular Weight: 228.088
• Mol File: 124623-15-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-propionyl-4-bromoaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-propionyl-4-bromoaniline(124623-15-0)
• EPA Substance Registry System: 2-propionyl-4-bromoaniline(124623-15-0)

Safety Data

• Hazardous Substances Data: 124623-15-0(Hazardous Substances Data)

Usage

Description

2-Propionyl-4-bromoaniline is a chemical compound with the molecular formula C10H11BrNO. It is a yellow crystalline solid that is used in the pharmaceutical and chemical industries. As an aniline derivative, it contains a benzene ring with an amino group (-NH2) attached to it. The presence of a propionyl group (-C3H7O) and a bromine atom in its structure gives it unique properties and potential applications.

Uses

Used in Pharmaceutical Industry:
2-Propionyl-4-bromoaniline is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs and medications.
Used in Chemical Industry:
2-Propionyl-4-bromoaniline is also used in the chemical industry for the synthesis of dyes and other organic compounds. Its versatility in chemical reactions makes it a valuable asset in the creation of a wide range of products.
Used in Research and Development:
Due to its unique properties, 2-Propionyl-4-bromoaniline is utilized in research and development for exploring new chemical reactions and applications. It can be a starting point for creating new compounds with potential uses in various industries.
It is important to handle and store 2-Propionyl-4-bromoaniline with proper safety measures, as it may be harmful if ingested, inhaled, or if it comes into contact with the skin.

Upstream product

• 188256-42-0 N-(4-bromo-2-propanoylphenyl)acetamide 
• 106-40-1 4-bromo-aniline 
• 107-12-0 propiononitrile 
• 52457-99-5 1-(2-acetylaminophenyl)-1-propanone 
• 811-49-4 ethyllithium 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 39263-32-6 2-amino-5-bromobenzonitrile 
• 925-90-6 ethylmagnesium bromide 

Downstream Products

• 1118760-74-9 C₁₃H₁₄BrNO₂ 
• 1075701-37-9 1-(2-amino-5-bromophenyl)-1-thiophen-2-yl-propan-1-ol 

Relevant articles and documents

Design of new reaction conditions for the Sugasawa reaction based on mechanistic insights

A process to prepare 2-propionyl-4-bromoaniline by ortho acylation of 4-bromoaniline under Sugasawa conditions was developed. Upon scale-up in a pilot plant, the process gave lower yields than in the laboratory in four out of five plant runs. Analysis of

Catalyst-free geminal aminofluorination of ortho-sulfonamide-tethered alkylidenecyclopropanes via a Wagner-Meerwein rearrangement

A catalyst-free intramolecular geminal aminofluorination of ortho-sulfonamide-tethered alkylidenecyclopropanes has been developed. The reaction proceeded through two SET processes with Selectfluor to give a fluorinated cyclopropylcarbinyl cation and a further Wagner-Meerwein rearrangement to generate a cyclobutyl carbocation, which undergoes intramolecular nucleophilic capture by amide to forge fluorinated cyclobuta[b]indoline derivatives. A polycyclic multi-fluorinated byproduct was also formed through a Ritter-type reaction in some cases.

1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing a 7-(5′-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators

A series of novel 7-(5′-cyanopyrrol-2-yl) substituted benzo[1,4]oxazepin-2-ones were prepared and tested for their progesterone receptor (PR) agonist or antagonist activity in the alkaline phosphatase assay using the human T47D breast carcinoma cell line.