124645-45-0

Basic information

• Product Name: 2-[(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)sulfanyl]-N-[2-(diethylamino)ethyl]acetamide
• CAS NO: 124645-45-0
• Molecular Formula: C₂₂H₂₇ClN₂OS₂
• Molecular Weight: 435.0456
• Mol File: 124645-45-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 586.4°C at 760 mmHg
• Flash Point: 308.4°C
• Density: 1.26g/cm³
• Vapor Pressure: 9.83E-14mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 2-[(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)sulfanyl]-N-[2-(diethylamino)ethyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)sulfanyl]-N-[2-(diethylamino)ethyl]acetamide(124645-45-0)
• EPA Substance Registry System: 2-[(2-chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yl)sulfanyl]-N-[2-(diethylamino)ethyl]acetamide(124645-45-0)

Safety Data

• Hazardous Substances Data: 124645-45-0(Hazardous Substances Data)

Upstream product

• 134674-00-3 (2-Chloro-10,11-dihydro-dibenzo[b,f]thiepin-10-ylsulfanyl)-acetic acid ethyl ester 
• 100-36-7 N,N-diethylethylenediamine 
• 133242-15-6 2-chloro-10,11-dihydrodibenzothiepin-10-thiol 
• 134673-95-3 4-(2-chloro-10,11-dihydrodibenzothiepin-10-ylthio)butyric acid 
• 134674-01-4 ethyl 4-(2-chloro-10,11-dihydrodibenzothiepin-10-ylthio)butyrate 
• 133242-16-7 S-(2-chloro-10,11-dihydrodibenzothiepin-10-yl)isothiuronium chloride 
• 4925-65-9 2,10-dichloro-10,11-dihydrodibenzothiepin 
• 56934-18-0 docloxythepin 

Relevant articles and documents

POTENTIAL NEUROTROPIC AND ANTIINFLAMMATORY AGENTS: 2-CHLORO-10,11-DIHYDRODIBENZOTHIEPIN-10-YL SULFIDES

2-Chloro-10,11-dihydrodibenzothiepin-10-thiol (VII) was synthesized from 2,10-dichloro-10,11-dihydrodibenzothiepin (IV) and was alkylated with a series of aminoalkyl chlorides which led to amino sulfides IX,XII, XIII, and XVI-XX.The primary amine IXa was transformed by treatment with ethyl chloroformate to the carbamate Xa which was reduced to the methylamino compound XIa.The carbamate XX was similarly reduced to compound XXI.Alkylation of VII with 2-bromoethanol gave the alcohol XIVa which was transformed to the crude tosylate XVa.Its reactions with the corresponding piperazines gave compounds XXII to XXIV.The alcohol XXII was esterified to the decanoate XXV.Reactions of the sodium salt of VII with ethyl chloroacetate, ethyl 2-chloropropionate and ethyl 4-chlorobutyrate gave the corresponding esters which were saponified to acids XXVIb-XXVIIIb.Their amides XXVId to XXVIIId and XXVIe were prepared either via the acid chlorides or via the esters.Out of the compounds prepared only XIa showed a clear profile of a potential antidepressant.The other compounds showed indications of thymoleptic, antiinflammatory and antimicrobial activities.