1246535-95-4 Usage
Description
5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine is a desmethyl analog of the dual PI3K/mTOR inhibitor VS-5584, which acts as a dual inhibitor of PI3Kα and mammalian target of rapamycin (mTOR) with IC50s of 17 and 150 nM, respectively.
Used in Pharmaceutical Industry:
5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine is used as a dual inhibitor for targeting both PI3Kα and mTOR pathways, which play crucial roles in cell growth, proliferation, and survival. Its application in this industry is aimed at developing potential therapeutic agents for the treatment of various diseases, including cancer, where these pathways are often dysregulated.
Used in Cancer Research:
In cancer research, 5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine is used as a research tool to study the role of PI3K/mTOR signaling in tumorigenesis and to evaluate its potential as a therapeutic agent for cancer treatment. Its dual inhibitory activity allows for the investigation of the combined effects of targeting both pathways in preclinical cancer models.
Used in Drug Development:
5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine is used as a lead compound in drug development efforts to discover novel and effective therapies for diseases associated with the dysregulation of PI3K/mTOR signaling. Its desmethyl analog structure provides a starting point for further optimization and refinement to improve potency, selectivity, and pharmacokinetic properties.
Used in Biochemical Assays:
In biochemical assays, 5-(9-isopropyl-2-Morpholino-9H-purin-6-yl)pyriMidin-2-aMine is used as a specific inhibitor to probe the activity and function of PI3Kα and mTOR enzymes. This allows researchers to gain insights into the molecular mechanisms underlying the regulation of these pathways and their contribution to disease pathogenesis.
Check Digit Verification of cas no
The CAS Registry Mumber 1246535-95-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,6,5,3 and 5 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1246535-95:
(9*1)+(8*2)+(7*4)+(6*6)+(5*5)+(4*3)+(3*5)+(2*9)+(1*5)=164
164 % 10 = 4
So 1246535-95-4 is a valid CAS Registry Number.
1246535-95-4Relevant articles and documents
As an inhibitor pyrimidinecarboxylic substd. hydroxyaminopurine compd. serinekinase
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, (2016/12/16)
PROBLEM TO BE SOLVED: To provide a pyrimidine substituted purine compound which can be used as a kinase inhibitor in a treatment of serine/threonine protein kinase related disorders/conditions, for example cancer, pre-cancer conditions or hyperplasia, autoimmune or inflammatory diseases or diseases caused by excessive angiogenesis.SOLUTION: There are provided 5-(9-isopropyl-8-methyl-2-morpholine-4-yl-9H-purine-6-yl)-pyrimidine-2-yl amine, preparation method thereof, and pharmaceutical compositions containing the compound.
8-SUBSTITUTED-2-MORPHOLINO PURINES FOR USE AS PI3K AND/OR MTOR INHIBITORS IN THE TREATMENT OF PROLIFERATIVE DISORDERS
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Page/Page column 76-77, (2010/11/03)
The present invention relates to purine compounds of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases.
