1246610-76-3

Basic information

• Product Name: Alogliptin trifluoroacetate
• Synonyms: Alogliptin trifluoroacetate
• CAS NO: 1246610-76-3
• Molecular Weight: 453.421
• Mol File: 1246610-76-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Alogliptin trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Alogliptin trifluoroacetate(1246610-76-3)
• EPA Substance Registry System: Alogliptin trifluoroacetate(1246610-76-3)

Safety Data

• Hazardous Substances Data: 1246610-76-3(Hazardous Substances Data)

Upstream product

• 1246610-74-1 2-[[6-[(3R)-3-tert-butoxycarbonylamino-1-piperidinyl]-3,4-dihydro-2,4-dioxo-3-methyl-1(2H)-pyrimidinyl]methyl]benzonitrile 
• 76-05-1 trifluoroacetic acid 
• 334618-23-4 3-(R)-aminopiperidine dihydrochloride 
• 865758-96-9 2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF ALOGLIPTIN

The present invention is based on the discovery of a process for preparing pyrimidin- dione compounds, especially alogliptin and its derivatives, which comprises the reaction of a urea derivative of formula (VIII) with a malonic acid or its derivatives to form intermediates of formulae (VII) or (VII-A), which are subsequently converted to a compound of formula (II) upon introduction of a leaving group X. Compound (II) then reacts with an amine to form compound (I), which is optionally converted to its salts of formula (IV).