1247-64-9 Usage
Description
Pregnenolone sulfate is a neuroactive metabolite of pregnenolone. It
has significant regulatory effects on the release of many important
neurotransmitters such as glutamate, GABA, acetylcholine,
norepinephrine, and dopamine.
Discovery
The presence of high amounts of
pregnenolone sulfate in the rat brain was reported, and it was found
that the concentration of this sulfated steroid was not affected by
adrenalectomy and castration.
Regulation of synthesis and release
Neuropeptide Y inhibits the
biosynthesis of pregnenolone sulfate in the frog hypothalamus through
activation of the Y1 receptor.Gonadotropin-releasing hormone (GnRH)
stimulates the biosynthesis of pregnenolone sulfate in the frog
hypothalamus.
Biological functions
Pregnenolone
sulfate has multiple important effects on brain functions, such as
cognitive enhancing, promnesic, antistress, and antidepressant effects.Pregnenolone sulfate also has significant regulatory effects on the
release of many important neurotransmitters such as glutamate, GABA,
acetylcholine, norepinephrine, and dopamine.
Clinical implications
Central acetylcholine
neurotransmission is known to be involved in the regulation of cognitive
processes and is affected in normal aging and severely altered in
human neurodegenerative pathologies such as Alzheimer’s disease.The
level of acetylcholine cortical release induced by the infusion of
pregnenolone sulfate was correlated to the spatial memory performance
of animals.The infusion of pregnenolone sulfate stimulated the
release of acetylcholine, suggesting that this effect could partly
explain the memory-enhancing properties of this neurosteroid.
Check Digit Verification of cas no
The CAS Registry Mumber 1247-64-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,4 and 7 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1247-64:
(6*1)+(5*2)+(4*4)+(3*7)+(2*6)+(1*4)=69
69 % 10 = 9
So 1247-64-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1
1247-64-9Relevant articles and documents
Testosterone sulfotransferase: Evidence in the guinea pig that this reaction is carried out by 3α-hydroxysteroid sulfotransferase
Park, Byoung C.,Lee, Young C.,Strott, Charles A.
, p. 510 - 517 (2007/10/03)
During the course of isolating, characterizing, and cloning estrogen and 3-hydroxysteroid sulfotransferases from the guinea pig adrenal gland, it was noted that cytosolic preparations from this tissue would also sulfonate testosterone. Therefore, we set out to isolate and clone the enzyme that performs this reaction. Testosterone sulfotransferase (TST) was isolated from the guinea pig adrenal by using the standard procedures of ion exchange, affinity, and high-performance liquid chromatography. When purified, TST was examined by liquid-phase nondenaturing isoelectric focusing, it was found that the TST activity profile completely overlapped with the activity profile of the 3α-hydroxysteroid sulfotransferase (3αHST) isoform, but not the 3β-hydroxysteroid sulfotransferase (3βHST) isoform. This finding was further investigated by overexpressing the cDNAs for 3αHST and 3βHST in Escherichia coli and examining the expressed proteins for TST activity. This experiment confirmed that 3αHST does indeed function as a TST. In addition, 3αHST was also found to sulfonate estradiol but not estrone, a finding that further suggested that 3αHST may function as a general 17β-hydroxysteroid sulfotransferase. Copyright (C) 1999.
