124703-77-1

Basic information

• Product Name: 3-Amino-4-methylpent-2-enoic acid methyl ester
• Synonyms: 3-Amino-4-methylpent-2-enoic acid methyl ester;Methyl 3-amino-4-methyl-2-pentenoate;Methyl 3-aMino-4-Methylpent-2-enoate
• CAS NO: 124703-77-1
• Molecular Formula: C₇H₁₃NO₂
• Molecular Weight: 143.18
• Mol File: 124703-77-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 223℃
• Flash Point: 91℃
• Appearance: /
• Density: 0.987
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Amino-4-methylpent-2-enoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-methylpent-2-enoic acid methyl ester(124703-77-1)
• EPA Substance Registry System: 3-Amino-4-methylpent-2-enoic acid methyl ester(124703-77-1)

Safety Data

• Hazardous Substances Data: 124703-77-1(Hazardous Substances Data)

Usage

General Description

3-Amino-4-methylpent-2-enoic acid methyl ester, also known as N-Methyl-L-norvaline, is a chemical compound with the molecular formula C8H15NO2. It is an amino acid derivative and a methyl ester that is commonly used as a building block in organic synthesis. 3-Amino-4-methylpent-2-enoic acid methyl ester is also known for its potential pharmaceutical applications, particularly as a potential inhibitor of enzymes involved in various metabolic pathways. Additionally, N-Methyl-L-norvaline has been studied for its potential role in promoting muscle protein synthesis and enhancing athletic performance. Overall, this compound has potential uses in both the pharmaceutical and fitness industries.

Upstream product

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Relevant articles and documents

Divergent Synthesis of Multisubstituted Unsymmetric Pyrroles and Pyrrolin-4-ones from Enamino Esters via Copper-Catalyzed Aerobic Dimerization

A facile synthetic method to access multisubstituted unsymmetric pyrrole and pyrrolin-4-one derivatives is disclosed. In the presence of Cu(OAc)2 and KOAc, substituted pyrrole derivatives are produced in good yields (up to 93 %) through oxidative cyclization of enamino esters. Meanwhile, using CuCl2 and TFA (trifluoroacetic acid), pyrrolin-4-one derivatives are obtained in excellent yields (up to 94 %) through 1,2-aryl migration. A wide range of functional groups have been tolerated, and a reliable method for the synthesis of valuable multisubstituted pyrroles and pyrrolin-4-ones has been developed.

Cu-Mediated Expeditious Annulation of Alkyl 3-Aminoacrylates with Aryldiazonium Salts: Access to Alkyl N2-Aryl 1,2,3-Triazole-carboxylates for Druglike Molecular Synthesis

Alkyl N-aryl 1,2,3-triazole-carboxylates are important molecules or intermediates in medicinal chemistry, but the synthesis of N2-aryl counterparts remains elusive. Herein, we describe a Cu-mediated annulation reaction of alkyl 3-aminoacrylates with aryldiazonium salts, both of which are readily available substrates. Furthermore, alkyl 2-aminoacrylates are also viable substrates. Diverse alkyl N2-aryl 1,2,3-triazole-carboxylates and their analogues can be rapidly prepared under mild conditions. Especially, this protocol allows one to access several druglike variants of carbonic anhydrase inhibitors and celecoxib.

Facile entry to an efficient and practical enantioselective synthesis of a polycyclic cholesteryl ester transfer protein inhibitor

An efficient enantioselective synthesis of the chiral polycyclic cholesteryl ester transfer protein (CETP) inhibitor 1 has been developed. The synthesis was rendered practical for large scale via the development of a modified Hantzsch-type reaction to prepare the sterically hindered pyridine ring, enantioselective hydrogenation of hindered ketone 6 utilizing novel BIBOP-amino-pyridine derived Ru complex, efficient ICl promoted lactone formation, and a BF3 mediated hydrogenation process for diastereoselective lactol reduction. This efficient route was successfully scaled to produce multikilogram quantities of challenging CETP drug candidate 1.