1247072-49-6

Basic information

• Product Name: C₂₂H₂₅F₃N₂O₃Si
• CAS NO: 1247072-49-6
• Molecular Weight: 450.533
• Mol File: 1247072-49-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅F₃N₂O₃Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅F₃N₂O₃Si(1247072-49-6)
• EPA Substance Registry System: C₂₂H₂₅F₃N₂O₃Si(1247072-49-6)

Safety Data

• Hazardous Substances Data: 1247072-49-6(Hazardous Substances Data)

Upstream product

• 13630-19-8 2-methylbenzotrifluoride 
• 1247072-45-2 6-nitro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indole 

Relevant articles and documents

Regioselective oxidative arylation of indoles bearing N-alkyl protecting groups: Dual c-h functionalization via a concerted metalation-deprotonation mechanism

The most direct method for synthesizing 2-arylindoles is oxidative coupling of an arene with an indole. We have shown that both the activity and regioselectivity of this cross-coupling reaction are correlated with the acidity of the medium. This insight has been applied to predict the best conditions for the oxidative cross-coupling of N-alkylindoles, an important class of substrates that has heretofore been incompatible with the harsh conditions required for oxidative cross-coupling. Both experimental and computational data indicate that the mechanism for C-H palladation of both the indoles and simple arenes is best described as concerted metalation-deprotonation, regardless of the substitution on the arene.