1247119-83-0 Usage
Description
2-(4-ethylphenyl)-2-methylpropanoic acid is an organic compound that serves as an intermediate in the synthesis of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor. 2-(4-ethylphenyl)-2-methylpropanoic acid plays a crucial role in the development of pharmaceuticals targeting specific cancer-related pathways.
Uses
Used in Pharmaceutical Industry:
2-(4-ethylphenyl)-2-methylpropanoic acid is used as a key intermediate in the synthesis of Alectinib, a medication designed to inhibit the anaplastic lymphoma kinase (ALK) enzyme. This inhibition is crucial for blocking the resistant gatekeeper mutant, which in turn leads to a reduction in cell growth associated with certain types of cancer.
As an intermediate in the production of Alectinib, 2-(4-ethylphenyl)-2-methylpropanoic acid contributes to the development of targeted cancer therapies that can effectively combat tumor growth and potentially improve patient outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1247119-83-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,7,1,1 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1247119-83:
(9*1)+(8*2)+(7*4)+(6*7)+(5*1)+(4*1)+(3*9)+(2*8)+(1*3)=150
150 % 10 = 0
So 1247119-83-0 is a valid CAS Registry Number.
1247119-83-0Relevant articles and documents
Preparation method and intermediate of halogenated aromatic hydrocarbon compound
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Paragraph 0142-0144, (2020/07/14)
The invention discloses a preparation method and an intermediate of a halogenated aromatic hydrocarbon compound, wherein the preparation method has the advantages of simple and accessible raw materials, low reagent price, high yield and simple operation,
Synthesis method of alectinib hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid
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Paragraph 0062-0064; 0068-0069; 0072; 0076-0077; 0080; 0084, (2020/12/29)
The invention discloses a synthesis method of an alectinib hydrochloride intermediate 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid. The method is characterized by comprising the following steps: reacting 4-ethyl acetophenone with a methyl Grignard reag
Preparation method of alectinib intermediate
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, (2019/03/15)
The invention discloses a preparation method of 2-(4-ethyl-3-iodine) phenyl-2-methyl propionic acid as an alectinib intermediate. According to the preparation method, the operation danger class and production cost are reduced by optimizing and improving a
