1247181-41-4Relevant articles and documents
Alkene dihydroxylation with malonoyl peroxides: Catalysis using fluorinated alcohols
Picon, Sylvain,Rawling, Michael,Campbell, Matthew,Tomkinson, Nicholas C. O.
, p. 6250 - 6253 (2013/02/23)
The effect of fluorinated alcohols on the dihydroxylation of alkenes using cyclopropyl malonoyl peroxide is described. Addition of perfluoro-tert-butyl alcohol to a toluene solution of alkene and peroxide increases the rate of product formation and the stereoselectivity observed, providing a simple and effective method for acceleration of this important class of reaction. Basic hydrolysis of the crude reaction mixture provides access to syn-diols in high yield and stereoselectivity.