124800-67-5Relevant articles and documents
TRANSFORMATION OF 5α-H-PREGN-16-EN-3β-OL-20-ONE INTO PREGN-4-ENE-9α,16α,17α-TRIOL-3,20-DIONE 16,17-ACETONIDE
Turuta, A. M.,Voishvillo, N. E.,Kamernitskii, A. V.,Dzhlantiashvili, N. V.,Korobov, A. A.
, p. 1482 - 1484 (2007/10/02)
A preparative method was proposed for the preparation of pregn-4-ene-9α,16α,17α-triol-3,20-dione 16α,17α-acetonide (2) from 5α-H-pregn-16-en-3β-ol-20-one (1).The key stage in the proposed sequence of the reactions is the microbiological 9α-hydroxylation and introduction of the 4-en-3-one grouping into the molecule of 1 by R- and S-dissociative forms of the Rhodococcus sp. strain. Keywords: pregnane derivatives, hydroxylation, oxidation, rhodococci, 16α-17α-acetonides of pregnanes, (R,S-variants).
SYNTHESIS OF 9α-HYDROXYSTEROIDS BY A RHODOCOCCUS SP.
Datcheva, Violeta K.,Voishvillo, Natalia E.,Kamernitskii, Aleksei V.,Vlahov, Radoslav J.,Reshetova, Irina G.
, p. 271 - 286 (2007/10/02)
9α-Hydroxylation of Δ5-3β-hydroxysteroids (of androstane, pregnane, 24-nor- and 21,24-bisnorcholane groups) was carried out by a Rhodococcus sp., isolated from a petroleum-containing soil sample.A large number of the investigated steroids was transformed into 9α-hydroxy-Δ4-3-ketones in satisfactory yields (50 - 90percent) at high initial concentrations of the substrates (0.5 - 5.0 g/L).The influence of some structural features of the steroid molecule on the progress and effectiveness of the microbial transformation was also shown.
