1248350-23-3

Basic information

• Product Name: C₁₈H₂₆O₂
• CAS NO: 1248350-23-3
• Molecular Weight: 274.403
• Mol File: 1248350-23-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₆O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₆O₂(1248350-23-3)
• EPA Substance Registry System: C₁₈H₂₆O₂(1248350-23-3)

Safety Data

• Hazardous Substances Data: 1248350-23-3(Hazardous Substances Data)

Upstream product

• 2432-84-0 octanethioic acid S-ethyl ester 
• 36004-04-3 ethyl (E)-1-phenylbut-1-en-3-ol 

Relevant articles and documents

Enantioselective synthesis of α-methyl carboxylic acids from readily available starting materials via chemoenzymatic dynamic kinetic resolution

An enantioselective method for the synthesis of α-methyl carboxylic acids starting from trans-cinnamaldehyde, a readily available and inexpensive compound, has been developed. Allylic alcohol 1 was obtained via a standard Grignard addition to trans-cinnamaldehyde. Dynamic kinetic resolution was applied to allylic alcohol 1 utilizing a ruthenium catalyst and either an (R)-selective lipase or an (S)-selective protease to provide the corresponding allylic esters in high yield and high ee. A copper-catalyzed allylic substitution was then applied to provide the corresponding alkenes with inversion of stereochemistry. Subsequent C-C double bond cleavage afforded pharmaceutically important α-methyl substituted carboxylic acids in high ee and overall yields of up to 76%.