1248544-66-2

Basic information

• Product Name: 4-(6-hydroxy-3-(4-(2-(piperidin-1-yl)ethoxy)phenylcarbonyl)benzo[b]thiophen-2-yl)phenyl benzoate
• Synonyms: 4-(6-hydroxy-3-(4-(2-(piperidin-1-yl)ethoxy)phenylcarbonyl)benzo[b]thiophen-2-yl)phenyl benzoate
• CAS NO: 1248544-66-2
• Molecular Weight: 577.701
• Mol File: 1248544-66-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(6-hydroxy-3-(4-(2-(piperidin-1-yl)ethoxy)phenylcarbonyl)benzo[b]thiophen-2-yl)phenyl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(6-hydroxy-3-(4-(2-(piperidin-1-yl)ethoxy)phenylcarbonyl)benzo[b]thiophen-2-yl)phenyl benzoate(1248544-66-2)
• EPA Substance Registry System: 4-(6-hydroxy-3-(4-(2-(piperidin-1-yl)ethoxy)phenylcarbonyl)benzo[b]thiophen-2-yl)phenyl benzoate(1248544-66-2)

Safety Data

• Hazardous Substances Data: 1248544-66-2(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 84449-90-1 Raloxifen 

Downstream Products

• 1248544-67-3 4-(3-(4-(2-(piperidin-1-yl)ethoxy)phenylcarbonyl)-6-(trifluoromethylsulfonyloxy)benzo[b]thiophen-2-yl)phenyl benzoate 

Relevant articles and documents

A mutant selective anti-estrogen is a pure antagonist on EREs and AP-1 response elements

Estrogen receptors (ERs) regulate gene transcription through classic estrogen response elements (EREs) as well as AP-1 responsive genes. The common SERMs Raloxifene, Tamoxifen, and ICI164384 function as ER antagonists on EREs but as ERβ agonists/partial agonists on AP-1 responsive genes. While developing a mutant selective analog of Raloxifene, that is an antagonist of ERα(E353A), we discovered an antagonist of wild-type ERα and ERβ that is also an antagonist of ERβ/AP-1 response. The analog, DRL527, represses basal AP-1 gene expression and antagonizes Raloxifene stimulated AP-1 expression. Therefore DRL527 has a unique, previously unreported, ERE/AP-1 activity profile.