1249725-52-7

Basic information

• Product Name: 2-(3-cyanophenyl)propanoic acid
• Synonyms: 2-(3-cyanophenyl)propanoic acid
• CAS NO: 1249725-52-7
• Molecular Weight: 175.187
• Mol File: 1249725-52-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(3-cyanophenyl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-cyanophenyl)propanoic acid(1249725-52-7)
• EPA Substance Registry System: 2-(3-cyanophenyl)propanoic acid(1249725-52-7)

Safety Data

• Hazardous Substances Data: 1249725-52-7(Hazardous Substances Data)

Upstream product

• 6952-59-6 3-cyanobromobenzene 
• 31469-22-4 1,1-bis(trimethylsilyloxy)prop-1-ene 
• 52798-00-2 (3-cyano-phenyl)-acetic acid methyl ester 
• 1878-71-3 2-(3-cyanophenyl)acetic acid 
• 1249463-71-5 methyl 2-(3-cyanophenyl)propanoate 
• 124-38-9 carbon dioxide 
• 1253037-64-7 1-(m-cyanophenyl)ethyl methyl carbonate 

Downstream Products

• 1428764-16-2 2-(3-(methylsulfonamidomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428765-29-0 2-(3-cyanophenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428789-43-8 2-(3-(methylsulfonamidomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1249463-71-5 methyl 2-(3-cyanophenyl)propanoate 
• 1428765-30-3 2-(3-(aminomethyl)phenyl)-N-((2-m-tolyl-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428790-15-1 2-(3-cyanophenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428790-13-9 2-(3-cyanophenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428790-16-2 2-(3-(aminomethyl)phenyl)-N-((2-(pyrrolidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 
• 1428789-42-7 N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)-2-(3-(methylsulfonamidomethyl)phenyl)propanamide 
• 1428790-14-0 2-(3-(aminomethyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide 

Relevant articles and documents

Palladium-Catalyzed α-Arylation of Carboxylic Acids and Secondary Amides via a Traceless Protecting Strategy

A novel traceless protecting strategy is presented for the long-standing challenge of conducting the palladium-catalyzed α-arylation of carboxylic aids and secondary amides with aryl halides. Both of the presented coupling processes occur with a variety of carboxylic acids and amides and with a variety of aryl bromides containing a broad range of functional groups, including base-sensitive functionality like acyl, alkoxycarbonyl, nitro, cyano, and even hydroxyl groups. Five commercial drugs were prepared through this method in one step in 81-96% yield. Gram-scale synthesis of medication Naproxen and Flurbiprofen with low palladium loading further highlights the practical value of this method.

Amine Substituted Methanesulfonamide Derivatives as Vanilloid Receptor Ligands

The invention relates to amine substituted methanesulfonamide derivatives as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

ARYL OR N-HETEROARYL SUBSTITUTED METHANESULFONAMIDE DERIVATIVES AS VANILLOID RECEPTOR LIGANDS

The invention relates to aryl or N-heteroaryl substituted methanesulfonamide derivatives of Formula (I) as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.