124993-49-3

Basic information

• Product Name: Benzeneacetonitrile, 2-[[4-(2-quinolinylmethoxy)phenoxy]methyl]-
• CAS NO: 124993-49-3
• Molecular Formula: C25H20N2O2
• Molecular Weight: 380.446
• Mol File: 124993-49-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzeneacetonitrile, 2-[[4-(2-quinolinylmethoxy)phenoxy]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetonitrile, 2-[[4-(2-quinolinylmethoxy)phenoxy]methyl]-(124993-49-3)
• EPA Substance Registry System: Benzeneacetonitrile, 2-[[4-(2-quinolinylmethoxy)phenoxy]methyl]-(124993-49-3)

Safety Data

• Hazardous Substances Data: 124993-49-3(Hazardous Substances Data)

Upstream product

• 3747-74-8 2-(chloromethyl)quinoline monohydrochloride 
• 91-63-4 2-methylquinoline 
• 773837-37-9 sodium cyanide 
• 612-12-4 o-Xylylene dichloride 
• 124993-40-4 2-[(4-hydroxyphenoxy)methyl]quinoline 
• 143-33-9 sodium cyanide 
• 124993-48-2 2-<<4-(2-quinolinylmethoxy)phenoxy>methyl>benzyl chloride 
• 187879-24-9 1-(4-Hydroxy-phenoxy)-3-(triphenyl-λ⁵-phosphanylidene)-propan-2-one 
• 151-50-8 potassium cyanide 

Downstream Products

• 120128-20-3 2-[[4-[[2-(1H-tetrazol-5-ylmethyl)phenyl]methoxy]phenoxy]methyl]quinoline 

Relevant articles and documents

Therapeutic uses of tri-aryl acid derivatives

The use of triaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.

Approaches to p-hydroxyphenoxymethylquinolines which avoid intermediate chloromethylquinolines for the synthesis of the LTD4 antagonist, RG 12525

As part of an effort to develop an industrial synthesis of the LTD4 antagonist RG 12525 (1), several approaches to the intermediate (2-quinolinylmethoxy)phenol 3 were investigated that avoided the generation of the lachrymatory sensitizer α-chloro-2-methylquinoline 2. Utilization of a cyclic sulfate in place of α,α'dichloro-o-xylene 4 showed promise as a selective dialkylating agent in the conversion of 3 to RO 12525 (1).