124996-01-6

Basic information

• Product Name: (E)-2-(4-hydroxybenzylidene)-2,3-dihydro-1H-inden-1-one
• Synonyms: (E)-2-(4-hydroxybenzylidene)-2,3-dihydro-1H-inden-1-one
• CAS NO: 124996-01-6
• Molecular Weight: 236.27
• Mol File: 124996-01-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: (E)-2-(4-hydroxybenzylidene)-2,3-dihydro-1H-inden-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(4-hydroxybenzylidene)-2,3-dihydro-1H-inden-1-one(124996-01-6)
• EPA Substance Registry System: (E)-2-(4-hydroxybenzylidene)-2,3-dihydro-1H-inden-1-one(124996-01-6)

Safety Data

• Hazardous Substances Data: 124996-01-6(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 83-33-0 inden-1-one 
• 100-52-7 benzaldehyde 
• 501-52-0 3-Phenylpropionic acid 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 268559-87-1 4-(1,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenol 
• 1631747-93-7 2-(4-(2-oxo-2-phenylethoxy)benzylidene)-2,3-dihydro-1H-inden-1-one 
• 1631747-96-0 2-(4-(2-(4-chlorophenyl)-2-oxoethoxy)benzylidene)-2,3-dihydro-1H-inden-1-one 

Relevant articles and documents

The inhibitory effects of phenolic Mannich bases on carbonic anhydrase I and II isoenzymes

Phenolic mono Mannich bases [2-[4-hydroxy-3-(aminomethyl)benzylidene]-2,3-dihydro-1H-inden-1-one (8–15)] and bis Mannich bases [2-[4-hydroxy-3,5-bis(aminomethyl)benzylidene]-2, 3-dihydro-1H-inden-1-one (2–7)] were synthesized starting from 2-(4-hydroxyben

Modified 2,4-diaryl-5H-indeno[1,2-b]pyridines with hydroxyl and chlorine moiety: Synthesis, anticancer activity, and structure-activity relationship study

As a part of ongoing studies in developing novel anticancer agents, a series of modified 2,4-diaryl-5H-indeno[1,2-b]pyridines were designed, and synthesized by introducing hydroxyl and chlorine moieties. They were evaluated for topoisomerase inhibitory ac

Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities

Chalcones and Mannich bases are a group of compounds known for their cytotoxicities. In this study restricted chalcone analogue, compound 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one MT1, was used as a starting compound to synthesize new mono Mannich b

Green, rapid, and highly efficient syntheses of α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones as potentially biologic compounds via solvent-free microwave-assisted Claisen–Schmidt condensation catalyzed by MoCl5

A new, green, and highly efficient protocol for the expeditious preparation of some α,α′-bis[(aryl or allyl)idene]cycloalkanones and 2-[(aryl or allyl)idene]-1-indanones via a simple microwave-assisted Claisen–Schmidt condensation reaction catalyzed by MoCl5 was successfully developed. Outstanding features of the current methodology include the use of solvent-free conditions, simple operation, use of a very inexpensive and available catalyst, low catalyst loading, short reaction times, high yields of the pure products, no harmful by-products, easy workup, and also the applicability of microwave irradiation as a clean source of energy. Furthermore, a gram-scale reaction was successfully conducted, proving the scalability of this current Claisen–Schmidt condensation reaction.

Novel 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors

On the basis of previous reports on the importance of thienyl, furyl or phenol group substitution on 5H-indeno[1,2-b]pyridine skeleton, a new series of rigid 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridine derivatives were systematically designed and